Teachers at the NASUWT union have voted in favour of industrial action in a dispute over pay.
Almost 90% of union members who voted backed strike action.
Nearly 95% supported action short of strike, with a turnout of 51.9% – passing the 50% ballot turnout required by law.
NASUWT said it will consider dates for strike action in the autumn term and will coordinate strikes with other unions where possible.
Dr Patrick Roach, the union’s general secretary, said: “Today our members have sent a strong message to the government and to employers that teachers demand a better deal on pay and to address excessive workload and working hours.
“Our members have secured the largest mandate for industrial action by the NASUWT in over a decade, exceeding the government’s anti-trade union ballot thresholds.
“We have today written to the government and to employers confirming the prospect for industrial action in schools the length and breadth of the country from this autumn.”
Royal Mail strikes end as postal workers vote to accept pay deal
Amazon warehouse workers to strike for three days next week, clashing with Prime Day sales
Junior doctors in Scotland suspend strikes following revised pay deal
Dr Roach added. “Our members’ goodwill has been taken for granted for far too long.
“Excessive workload demands have become so debilitating that we have seen record numbers of teachers and headteachers leaving the profession, or reporting anxiety, work-related stress and self-harm because of the pressures of the job.
“No teacher should expect to work in conditions damaging to their health and wellbeing. Ministers cannot continue to wring their hands and do nothing.
“Our members deserve better and pupils deserve better, too. The Government cannot continue to ignore the damaging impact that the teacher recruitment and retention crisis is having on pupils’ education.”