Wetherspoons has become the latest well-known business to experience supply shortages with some of its beers not available.
A spokesman said the pub chain was experiencing supply problems with Carling and Coors and apologised to customers.
It is the latest company to be affected by shortages across the economy – following the likes of Nando’s, McDonald’s and Greggs.
The shortages have been widely blamed on a tangle of issues stemming from both the pandemic and Brexit.
Wetherspoons spokesman Eddie Gershon said: “We are experiencing some supply problems with both Carling and Coors, which means that some pubs do not have the products available.
“We apologise to our customers for any inconvenience caused.
“We know that the brewers are trying to resolve the issue.”
Wetherspoons did not go into further details about the nature of or reason for its supply problems.
But the shortage prompted further criticism on social media of chairman Tim Martin’s outspoken support for Brexit.
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One Twitter user claimed Mr Martin had “been instrumental in creating the labour and supply shortages now affecting him” while another commented that “the horrors of Brexit are finally dawning on Tim Martin”.
Supply strains have become strained over recent weeks partly thanks to the shortage of an estimated 100,000 HGV drivers – an issue blamed both on Brexit and the pandemic.
Another key problem over the summer has been that of workers across the economy being forced to stay at home because of COVID-19 app alerts.
Wetherspoons had been one of the victims of that so-called pingdemic with “a couple of hundred” staff off and some pubs having to open later than usual.
Spokesman Mr Gershon said today that he was not aware of any sites having to operate shorter hours at present.
Elsewhere, the poultry and pig industries have said they are short of European workers.
The government has rejected calls from business for a temporary loosening of post-Brexit immigration rules to try to ease the supply chain crisis.
Sky News has contacted brewer Molson Coors for comment