Holidaymakers planning on going on a “staycation cruise” will have to prove they have had both doses of a vaccine or they will not be allowed on board.
The decision by P&O Cruises comes as the hospitality industry braces itself for the end of a difficult 12 months due to coronavirus lockdown restrictions.
A spokesman for the UK’s largest cruise line said this is a “strong expressed preference on the part of our guests”.
Other measures introduced due to the pandemic include requiring passengers to wear masks in certain areas of the ship, and making travel insurance mandatory.
There will also be enhanced cleaning regimes and social distancing, while buffet food will be served by staff.
Saga Cruises has previously announced it will require all guests to be vaccinated when it resumes operations in June.
P&O Cruises will operate a series of short breaks on Britannia, while new ship Iona will conduct seven-night itineraries – all around the UK coastline.
On 12 April outdoor attractions such as theme parks will be allowed to reopen as well as outdoor hospitality, including pubs and restaurants – with the rule of six or a larger group from two households.
Self-catering holidays in the UK with your own household will also be allowed.
On the same day, the Government’s Global Travel Taskforce will provide a report to the prime minister setting out recommendations for how and when foreign holidays could resume.
They could be permitted for people in England from May 17 under the Boris Johnson’s road map for easing restrictions.
Turkey announced on Monday that it expects to welcome UK holidaymakers this summer without requiring proof of a coronavirus vaccine or negative test.
Greece will require international tourists to have been vaccinated, had a recent negative COVID-19 test or have coronavirus antibodies, while visitors to Cyprus must have had both doses of a vaccine.