A mother was stabbed to death in Bethnal Green, east London, while her children were at school, the Metropolitan Police has said.
The 40-year-old victim was found with stab injuries at an address in Globe Road on Thursday afternoon, where she was pronounced dead at the scene.
The alert was raised at 4.06pm after the woman had failed to pick up her children from school.
The woman has not yet been formally identified, but her next of kin have been informed, officers said.
A post-mortem will take place on Saturday.
Detective Chief Inspector Laurence Smith, who is leading the murder investigation, said it was “heartbreaking that yet another woman has been killed”.
“A dedicated team of officers is working around the clock to trace the person responsible for this and my thoughts are with this woman’s family as they come to terms with their tragic loss,” she said.
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“All women and girls have the right to feel safe, at any time, day or night, in public or at home, and we will do everything we can to find those responsible for this.”
She added that police remain at the scene and will continue to carry out door-to-door inquiries.
Anyone with any information has been asked to call police on 101 quoting CAD 4738/24Mar. Alternatively, they can remain anonymous by contacting the independent charity Crimestoppers on 0800 555 111.