People who experience a headache for more than four days after having the Oxford-AstraZeneca jab should seek medical attention, the UK’s medicines regulator has said.

They should also get help if they have bruising somewhere other than the injection site after a few days, it added.

The Medicines and Healthcare products Regulatory Agency (MHRA) said on Thursday it was looking into a “very small” number of reports of an extremely rare form of blood clot that occurs in conjunction with lowered platelets after vaccination.

Called sinus vein thrombosis (CVST), it describes the formation of a blood clot in the cerebral vein of the brain.

There have been five cases reported to the MHRA, which has assured the condition can also occur naturally in people who have not been vaccinated and who have COVID-19.

It stressed that no causal link with the AstraZeneca vaccine had been found, adding that investigations would continue.

Meanwhile, the agency said a “rigorous” scientific review had found no evidence that the AstraZeneca vaccine against COVID-19 caused blood clots in veins.

Current advice is to still attend vaccination appointments as scheduled.

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